Tacrolimus CAS 104987-11-3 Reduce Immune System Rejection C44H69NO12
Melting Point: 113-115° C
Boiling Point: 871.7 ° C at 760 mmHg
Appearance: White powder
Lead time: 1-2 days upon receipt of payment
Delivery time: Usually 4-6 working days by air
Storage: Store in a cool, dry place. Do not store in direct
sunlight. Store in a tightly closed container.
1. Immunosuppression following transplantation
It has similar immunosuppressive properties to ciclosporin, but is
much more potent. Immunosuppression with tacrolimus was associated
with a significantly lower rate of acute rejection compared with
ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study.
Clinical outcome is better with tacrolimus than with ciclosporin
during the first year of liver transplantation. Long-term outcome
has not been improved to the same extent. Tacrolimus is normally
prescribed as part of a post-transplant cocktail including
steroids, mycophenolate, and IL-2 receptor inhibitors such as
basiliximab. Dosages are titrated to target blood levels.
2. Ulcerative colitis
In recent years, tacrolimus has been used to suppress the
inflammation associated with ulcerative colitis (UC), a form of
inflammatory bowel disease. Although almost exclusively used in
trial cases only, tacrolimus has shown to be significantly
effective in the suppression of outbreaks of UC.
3. Dermatological use
As an ointment, tacrolimus is used in the treatment of eczema, in
particular atopic dermatitis. It suppresses inflammation in a
similar way to steroids, and is equally as effective as a
mid-potency steroid. An important advantage of tacrolimus is that,
unlike steroids, it does not cause skin thinning (atrophy), or
other steroid related side effects. It is applied on the active
lesions until they heal off, but may also be used continuously in
low doses (twice a week), and applied to the thinner skin over the
face and eyelids. Clinical trials of up to one
year have been conducted. Recently it has also been used to treat
segmental vitiligo in children, especially in areas on the face.
Test of Tacrolimus
|Description||A white crystalline powder||Complies|
|Solubility||Soluble in Methanol, Ethyl acetate and Chloroform||Complies|
|Residue on ignition||≤0.10%||Complies|
|Assay ( on dry basis|
|Conclusion||The product conforms to the Enterprise specification.|
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